Coffee contains caffeine, a stimulant that can interfere with how Gabapentin 300 mg works in your body. While Gabapentin calms nerve activity to reduce pain, seizures, or anxiety, caffeine does the opposite by exciting your nervous system. This conflicting effect may reduce the medication’s effectiveness, cause increased side effects like dizziness, jitteriness, or sleep problems, and disrupt your mood balance. For these reasons, it’s important to be cautious with coffee consumption while taking Gabapentin 300 mg and consult your healthcare provider to find the right balance for you.